Prof. Dr. Peter Wieghofer
Professor für Zellul?re Neuroanatomie
Anatomie und Zellbiologie
| Telefon: | +49 (0) 821 598-2798 |
| E-Mail: | peter.wieghofer@med.uni-augsburgmed.uni-augsburg.de () |
| Raum: | 1005 (Sigma-Technopark Geb?ude 10) |
| Adresse: | Werner-von-Siemens-Stra?e 6 (Sigma Technopark), 86159 Augsburg |
Lebenslauf
2021???????
W2-Professur für Zellul?re Neuroanatomie
Universit?t Augsburg
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2021????????????????
Habilitation und Anerkennung der Lehrbefugnis im Fach Anatomie
Universit?t Leipzig
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2016 - 2021????
Arbeitsgruppenleiter im Fachbereich Anatomie, Institut für Anatomie (Prof. Dr. Ingo Bechmann)
Universit?t Leipzig
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2011 - 2016????
Dissertation am Institut für Neuropathologie an der Albert-Ludwigs-Universit?t (Prof. Dr. Marco Prinz)
Freiburg im Breisgau
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2007 - 2011????
Studium an der Eberhard Karls Universit?t (Diplom)
Universit?t Tübingen
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2005 - 2007????
Studium an der TU (Vordiplom)
Kaiserlautern
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Mitgliedschaften
- Mitglied der Anatomischen Gesellschaft
- Mitglied der Deutschen Gesellschaft für Immunologie
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Publikationen Prof. Dr. rer. nat. Peter Wieghofer
2024
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2023
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2022
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2021
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2020
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2018
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2016
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2015
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2014
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2013
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2024 |
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Lange Clemens, Boneva Stefaniya, Wieghofer Peter, Sebag J..
Hyalocytes — guardians of the vitreoretinal interface.
https://doi.org/10.1007/s00417-024-06448-3
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Rosmus Dennis-Dominik, Koch Jana, Hausmann Annika, Chiot Aude, Arnhold Franz, Masuda Takahiro, Kierdorf Katrin, Hansen Stefanie Marie, Kuhrt Heidrun, Fr?ba Janine, Wolf Julian, Boneva Stefaniya, Gericke Martin, Ajami Bahareh, Prinz Marco, Lange Clemens, Wieghofer Peter.
Redefining the ontogeny of hyalocytes as yolk sac-derived tissue-resident macrophages of the vitreous body.
https://doi.org/10.1186/s12974-024-03110-x
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2023 |
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Sch?ffner Erik, Bosch-Queralt Mar, Edgar Julia M., Lehning Maria, Strau? Judith, Fleischer Niko, Kungl Theresa, Wieghofer Peter, Berghoff Stefan A., Reinert Tilo, Krueger Martin, Morawski Markus, M?bius Wiebke, Barrantes-Freer Alonso, Stieler Jens, Sun Ting, Saher Gesine, Schwab Markus H., Wrede Christoph, Frosch Maximilian, Prinz Marco, Reich Daniel S., Flügel Alexander, Stadelmann Christine, Fledrich Robert, Nave Klaus-Armin, Stassart Ruth M..
Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease.
https://doi.org/10.1038/s41593-023-01366-9
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Sch?ffner Erik, Bosch-Queralt Mar, Edgar Julia M., Lehning Maria, Strau? Judith, Fleischer Niko, Kungl Theresa, Wieghofer Peter, Berghoff Stefan A., Reinert Tilo, Krueger Martin, Morawski Markus, M?bius Wiebke, Barrantes-Freer Alonso, Stieler Jens, Sun Ting, Saher Gesine, Schwab Markus H., Wrede Christoph, Frosch Maximilian, Prinz Marco, Reich Daniel S., Flügel Alexander, Stadelmann Christine, Fledrich Robert, Nave Klaus-Armin, Stassart Ruth M..
Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease [Abstract].
https://doi.org/10.1002/glia.24419
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2022 |
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Wolf Julian, Schlecht Anja, Rosmus Dennis-Dominik, Boneva Stefaniya, Agostini Hansjürgen, Schlunck Günther, Wieghofer Peter, Lange Clemens.
Comparative transcriptome analysis of human and murine choroidal neovascularization identifies fibroblast growth factor inducible-14 as phylogenetically conserved mediator of neovascular age-related macular degeneration.
https://doi.org/10.1016/j.bbadis.2022.166340
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Wolf Julian, Boneva Stefaniya, Rosmus Dennis-Dominik, Agostini Hansjürgen, Schlunck Günther, Wieghofer Peter, Schlecht Anja, Lange Clemens.
Deciphering the molecular signature of human hyalocytes in relation to other innate immune cell populations.
https://doi.org/10.1167/iovs.63.3.9
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Boneva Stefaniya K., Wolf Julian, Wieghofer Peter, Sebag J., Lange Clemens A. K..
Hyalocyte functions and immunology.
https://doi.org/10.1080/17469899.2022.2100763
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Wieghofer Peter, Engelbert Michael, Chui Toco Y. P., Rosen Richard B., Sakamoto Taiji, Sebag J..
Hyalocyte origin, structure, and imaging.
https://doi.org/10.1080/17469899.2022.2100762
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Wolf Julian, Boneva Stefaniya K., Rosmus Dennis-Dominik, Agostini Hansjürgen, Schlunck Günther, Wieghofer Peter, Schlecht Anja, Lange Clemens.
In-depth molecular profiling specifies human retinal microglia identity.
https://doi.org/10.3389/fimmu.2022.863158
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Rosmus Dennis-Dominik, Lange Clemens, Ludwig Franziska, Ajami Bahareh, Wieghofer Peter.
The role of osteopontin in microglia biology: current concepts and future perspectives.
https://doi.org/10.3390/biomedicines10040840
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Zhuang Xinyu, Schlunck Günther, Wolf Julian, Rosmus Dennis-Dominik, Bleul Tim, Luo Ren, B?hringer Daniel, Wieghofer Peter, Lange Clemens, Reinhard Thomas, Lapp Thabo.
Time- and stimulus-dependent characteristics of innate immune cells in organ-cultured human corneal tissue.
https://doi.org/10.1159/000516669
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Schlecht Anja, Wolf Julian, Boneva Stefaniya, Prinz Gabriele, Braunger Barbara M., Wieghofer Peter, Agostini Hansjürgen, Schlunck Günther, Lange Clemens.
Transcriptional and distributional profiling of microglia in retinal angiomatous proliferation.
https://doi.org/10.3390/ijms23073443
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2021 |
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Lindhorst Andreas, Raulien Nora, Wieghofer Peter, Eilers Jens, Rossi Fabio M. V., Bechmann Ingo, Gericke Martin.
Adipocyte death triggers a pro-inflammatory response and induces metabolic activation of resident macrophages.
https://doi.org/10.1038/s41419-021-03872-9
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Schlecht Anja, Thien Adrian, Wolf Julian, Prinz Gabriele, Agostini Hansjürgen, Schlunck Günther, Wieghofer Peter, Boneva Stefaniya, Lange Clemens.
Immunosenescence in choroidal neovascularization (CNV) — transcriptional profiling of na?ve and CNV-associated retinal myeloid cells during aging.
https://doi.org/10.3390/ijms222413318
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Wieghofer Peter, Hagemeyer Nora, Sankowski Roman, Schlecht Anja, Staszewski Ori, Amann Lukas, Gruber Markus, Koch Jana, Hausmann Annika, Zhang Peipei, Boneva Stefaniya, Masuda Takahiro, Hilgendorf Ingo, Goldmann Tobias, B?ttcher Chotima, Priller Josef, Rossi Fabio MV, Lange Clemens, Prinz Marco.
Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single‐cell profiling.
https://doi.org/10.15252/embj.2020105123
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Schlecht Anja, Zhang Peipei, Wolf Julian, Thien Adrian, Rosmus Dennis-Dominik, Boneva Stefaniya, Schlunck Günther, Lange Clemens, Wieghofer Peter.
Secreted phosphoprotein 1 expression in retinal mononuclear phagocytes links murine to human choroidal neovascularization.
https://doi.org/10.3389/fcell.2020.618598
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Tenbrock Louis, Wolf Julian, Boneva Stefaniya, Schlecht Anja, Agostini Hansjürgen, Wieghofer Peter, Schlunck Günther, Lange Clemens.
Subretinal fibrosis in neovascular age-related macular degeneration: current concepts, therapeutic avenues, and future perspectives.
https://doi.org/10.1007/s00441-021-03514-8
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Zhang Peipei, Schlecht Anja, Wolf Julian, Boneva Stefaniya, Laich Yannik, Koch Jana, Ludwig Franziska, Boeck Myriam, Thien Adrian, H?rdtner Carmen, Kierdorf Katrin, Agostini Hansjürgen, Schlunck Günther, Prinz Marco, Hilgendorf Ingo, Wieghofer Peter, Lange Clemens.
The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation.
https://doi.org/10.1186/s12974-021-02230-y
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2020 |
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Brioschi Simone, d’Errico Paolo, Amann Lukas S., Janova Hana, Wojcik Sonja M., Meyer-Luehmann Melanie, Rajendran Lawrence, Wieghofer Peter, Paolicelli Rosa C., Biber Knut.
Detection of synaptic proteins in microglia by flow cytometry.
https://doi.org/10.3389/fnmol.2020.00149
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Boeck Myriam, Thien Adrian, Wolf Julian, Hagemeyer Nora, Laich Yannik, Yusuf Dilmurat, Backofen Rolf, Zhang Peipei, Boneva Stefaniya, Stahl Andreas, Hilgendorf Ingo, Agostini Hansjürgen, Prinz Marco, Wieghofer Peter, Schlunck Günther, Schlecht Anja, Lange Clemens.
Temporospatial distribution and transcriptional profile of retinal microglia in the oxygen‐induced retinopathy mouse model.
https://doi.org/10.1002/glia.23810
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Boneva Stefaniya Konstantinova, Wolf Julian, Rosmus Dennis-Dominik, Schlecht Anja, Prinz Gabriele, Laich Yannik, Boeck Myriam, Zhang Peipei, Hilgendorf Ingo, Stahl Andreas, Reinhard Thomas, Bainbridge James, Schlunck Günther, Agostini Hansjürgen, Wieghofer Peter, Lange Clemens A. K..
Transcriptional profiling uncovers human hyalocytes as a unique innate immune cell population.
https://doi.org/10.3389/fimmu.2020.567274
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Schlecht Anja, Boneva Stefaniya, Gruber Markus, Zhang Peipei, Horres Ralf, Bucher Felicitas, Auw-Haedrich Claudia, Hansen Lutz, Stahl Andreas, Hilgendorf Ingo, Agostini Hansjürgen, Wieghofer Peter, Schlunck Günther, Wolf Julian, Lange Clemens A.K..
Transcriptomic characterization of human choroidal neovascular membranes identifies calprotectin as a novel biomarker for patients with age-related macular degeneration.
https://doi.org/10.1016/j.ajpath.2020.04.004
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2018 |
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Voet Sofie, Mc Guire Conor, Hagemeyer Nora, Martens Arne, Schroeder Anna, Wieghofer Peter, Daems Carmen, Staszewski Ori, Vande Walle Lieselotte, Jordao Marta Joana Costa, Sze Mozes, Vikkula Hanna-Kaisa, Demeestere Delphine, Van Imschoot Griet, Scott Charlotte L., Hoste Esther, Gon?alves Amanda, Guilliams Martin, Lippens Saskia, Libert Claude, Vandenbroucke Roos E., Kim Ki-Wook, Jung Steffen, Callaerts-Vegh Zsuzsanna, Callaerts Patrick, de Wit Joris, Lamkanfi Mohamed, Prinz Marco, van Loo Geert.
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation.
https://doi.org/10.1038/s41467-018-04376-5
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Ajami Bahareh, Samusik Nikolay, Wieghofer Peter, Ho Peggy P., Crotti Andrea, Bjornson Zach, Prinz Marco, Fantl Wendy J., Nolan Garry P., Steinman Lawrence.
Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models.
https://doi.org/10.1038/s41593-018-0100-x
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2016 |
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Wieghofer Peter, Prinz Marco.
Genetic manipulation of microglia during brain development and disease.
https://doi.org/10.1016/j.bbadis.2015.09.019
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Theurl Igor, Hilgendorf Ingo, Nairz Manfred, Tymoszuk Piotr, Haschka David, Asshoff Malte, He Shun, Gerhardt Louisa M S, Holderried Tobias A W, Seifert Markus, Sopper Sieghart, Fenn Ashley M, Anzai Atsushi, Rattik Sara, McAlpine Cameron, Theurl Milan, Wieghofer Peter, Iwamoto Yoshiko, Weber Georg F, Harder Nina K, Chousterman Benjamin G, Arvedson Tara L, McKee Mary, Wang Fudi, Lutz Oliver M D, Rezoagli Emanuele, Babitt Jodie L, Berra Lorenzo, Prinz Marco, Nahrendorf Matthias, Weiss Guenter, Weissleder Ralph, Lin Herbert Y, Swirski Filip K.
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver.
https://doi.org/10.1038/nm.4146
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Goldmann Tobias, Wieghofer Peter, Jord?o Marta Joana Costa, Prutek Fabiola, Hagemeyer Nora, Frenzel Kathrin, Amann Lukas, Staszewski Ori, Kierdorf Katrin, Krueger Martin, Locatelli Giuseppe, Hochgerner Hannah, Zeiser Robert, Epelman Slava, Geissmann Frederic, Priller Josef, Rossi Fabio M V, Bechmann Ingo, Kerschensteiner Martin, Linnarsson Sten, Jung Steffen, Prinz Marco.
Origin, fate and dynamics of macrophages at central nervous system interfaces.
https://doi.org/10.1038/ni.3423
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Hagemeyer Nora, Kierdorf Katrin, Frenzel Kathrin, Xue Jia, Ringelhan Marc, Abdullah Zeinab, Godin Isabelle, Wieghofer Peter, Costa Jord?o Marta Joana, Ulas Thomas, Yorgancioglu Gülden, Rosenbauer Frank, Knolle Percy A, Heikenwalder Mathias, Schultze Joachim L, Prinz Marco.
Transcriptome‐based profiling of yolk sac‐derived macrophages reveals a role for Irf8 in macrophage maturation.
https://doi.org/10.15252/embj.201693801
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2015 |
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Erny Daniel, Hrabě de Angelis Anna Lena, Jaitin Diego, Wieghofer Peter, Staszewski Ori, David Eyal, Keren-Shaul Hadas, Mahlakoiv Tanel, Jakobshagen Kristin, Buch Thorsten, Schwierzeck Vera, Uterm?hlen Olaf, Chun Eunyoung, Garrett Wendy S, McCoy Kathy D, Diefenbach Andreas, Staeheli Peter, Stecher B?rbel, Amit Ido, Prinz Marco.
Host microbiota constantly control maturation and function of microglia in the CNS.
https://doi.org/10.1038/nn.4030
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Gao Liang, Brenner David, Llorens-Bobadilla Enric, Saiz-Castro Gonzalo, Frank Tobias, Wieghofer Peter, Hill Oliver, Thiemann Meinolf, Karray Saoussen, Prinz Marco, Weishaupt Jochen H., Martin-Villalba Ana.
Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice.
https://doi.org/10.1084/jem.20132423
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Ensan Sherine, Li Angela, Besla Rickvinder, Degousee Norbert, Cosme Jake, Roufaiel Mark, Shikatani Eric A, El-Maklizi Mahmoud, Williams Jesse W, Robins Lauren, Li Cedric, Lewis Bonnie, Yun Tae Jin, Lee Jun Seong, Wieghofer Peter, Khattar Ramzi, Farrokhi Kaveh, Byrne John, Ouzounian Maral, Zavitz Caleb C J, Levy Gary A, Bauer Carla M T, Libby Peter, Husain Mansoor, Swirski Filip K, Cheong Cheolho, Prinz Marco, Hilgendorf Ingo, Randolph Gwendalyn J, Epelman Slava, Gramolini Anthony O, Cybulsky Myron I, Rubin Barry B, Robbins Clinton S.
Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth.
https://doi.org/10.1038/ni.3343
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2014 |
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Wieghofer Peter, Knobeloch Klaus-Peter, Prinz Marco.
Genetic targeting of microglia.
https://doi.org/10.1002/glia.22727
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Mc Guire Conor, Elton Lynn, Wieghofer Peter, Staal Jens, Voet Sofie, Demeyer Annelies, Nagel Daniel, Krappmann Daniel, Prinz Marco, Beyaert Rudi, van Loo Geert.
Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis.
https://doi.org/10.1186/1742-2094-11-124
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2013 |
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Goldmann Tobias, Wieghofer Peter, Müller Philippe F, Wolf Yochai, Varol Diana, Yona Simon, Brendecke Stefanie M, Kierdorf Katrin, Staszewski Ori, Datta Moumita, Luedde Tom, Heikenwalder Mathias, Jung Steffen, Prinz Marco.
A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation.
https://doi.org/10.1038/nn.3531
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Funk Natalja, Wieghofer Peter, Grimm Sabrina, Schaefer Richard, Bühring Hans-J?rg, Gasser Thomas, Biskup Saskia.
Characterization of peripheral hematopoietic stem cells and monocytes in Parkinson's disease.
https://doi.org/10.1002/mds.25300
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Kierdorf Katrin, Erny Daniel, Goldmann Tobias, Sander Victor, Schulz Christian, Perdiguero Elisa Gomez, Wieghofer Peter, Heinrich Annette, Riemke Pia, H?lscher Christoph, Müller Dominik N, Luckow Bruno, Brocker Thomas, Debowski Katharina, Fritz Günter, Opdenakker Ghislain, Diefenbach Andreas, Biber Knut, Heikenwalder Mathias, Geissmann Frederic, Rosenbauer Frank, Prinz Marco.
Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways.
https://doi.org/10.1038/nn.3318
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Mc Guire Conor, Wieghofer Peter, Elton Lynn, Muylaert David, Prinz Marco, Beyaert Rudi, van Loo Geert.
Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination.
https://doi.org/10.4049/jimmunol.1201351
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