2024
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Steinbrech Julian, Klein Till, Kirschke Stephanie, Mannell Hanna, Clau? Sebastian, Bertsche Thilo, Strobach Dorothea.
Determining sensitivity and specificity of risk scores for QTc interval prolongation in hemato-oncology patients prescribed systemic antifungal therapy: a retrospective cross-sectional study.
International Journal of Clinical Pharmacy 2024;
https://doi.org/10.1007/s11096-024-01788-w
BibTeX | RIS | DOI
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Kipka Hannah, Liebchen Uwe, Hübner Max, H?fner Georg, Frey Otto, Wanner Klaus T., Kilger Erich, Hagl Christian, Tomasi Roland, Mannell Hanna.
Serum concentrations of levosimendan and its metabolites OR-1855 and OR-1896 in cardiac surgery patients with cardiopulmonary bypass.
Frontiers in Cardiovascular Medicine 2024;11:1406338.
https://doi.org/10.3389/fcvm.2024.1406338
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2023
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Golla Kathrin, Benesic Andreas, Mannell Hanna, Dreischulte Tobias, Grill Eva, Strobach Dorothea.
Hepatic impairment as a risk factor for drug safety: suitability and comparison of four liver scores as screening tools.
Journal of Clinical Medicine 2023;12(21):6814.
https://doi.org/10.3390/jcm12216814
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Strobach Dorothea, Haimerl Lisa, Mannell Hanna, Stief Christian G., Karl Alexander, Grimm Tobias, Buchner Alexander.
The characterization of non-oncologic chronic drug therapy in bladder cancer patients and the impact on recurrence-free and cancer-specific survival: a prospective study.
Journal of Clinical Medicine 2023;12(21):6749.
https://doi.org/10.3390/jcm12216749
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Kipka Hannah, Schaflinger Rebecca, Tomasi Roland, Pogoda Kristin, Mannell Hanna.
The effects of the levosimendan metabolites OR-1855 and OR-1896 on endothelial pro-inflammatory responses.
Biomedicines 2023;11(3):918.
https://doi.org/10.3390/biomedicines11030918
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2022
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Hindelang V., Dimitriadis K., Saller T., Golla K., Mannell Hanna, Hug M. J., Strobach D..
A new medication-based prediction score for postoperative delirium in surgical patients: development and proof of feasibility in a retrospective patient cohort.
Die Pharmazie 2022;77(10):302-306.
https://doi.org/10.1691/ph.2022.2438
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Mannell Hanna, Kameritsch Petra, Beck Heike, Pfeifer Alexander, Pohl Ulrich, Pogoda Kristin.
Cx43 promotes endothelial cell migration and angiogenesis via the tyrosine phosphatase SHP-2.
International Journal of Molecular Sciences 2022;23(1):294.
https://doi.org/10.3390/ijms23010294
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Golla Kathrin, Mannell Hanna, Benesic Andreas, Dreischulte Tobias, Grill Eva, Strobach Dorothea.
Feasibility of the MELD score as a screening tool for pharmacists to identify patients with impaired hepatic function at hospital admission.
Journal of Clinical Pharmacy and Therapeutics 2022;47(5):676-684.
https://doi.org/10.1111/jcpt.13597
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Haimerl Lisa, Strobach Dorothea, Mannell Hanna, Stief Christian G., Buchner Alexander, Karl Alexander, Grimm Tobias.
Retrospective evaluation of the impact of non-oncologic chronic drug therapy on the survival in patients with bladder cancer.
International Journal of Clinical Pharmacy 2022;44(2):339-347.
https://doi.org/10.1007/s11096-021-01343-x
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Kipka Hannah, Tomasi Roland, Hübner Max, Liebchen Uwe, Hagl Christian, Wanner Klaus T., Mannell Hanna, H?fner Georg.
Simultaneous LC-ESI-MS/MS quantification of levosimendan and its metabolites for therapeutic drug monitoring of cardiac surgery patients.
Pharmaceutics 2022;14(7):1454.
https://doi.org/10.3390/pharmaceutics14071454
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2021
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Seiberth Sarah, Bauer Dominik, Sch?nermarck Ulf, Mannell Hanna, Stief Christian, Hasford Joerg, Strobach Dorothea.
Implementation of a renal pharmacist consultant service: information sharing in paper versus digital form.
Journal of Clinical Pharmacy and Therapeutics 2021;46(3):838-845.
https://doi.org/10.1111/jcpt.13371
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2020
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Seiberth Sarah, Bauer Dominik, Sch?nermarck Ulf, Mannell Hanna, Stief Christian, Hasford Joerg, Strobach Dorothea.
Correct use of non-indexed eGFR for drug dosing and renal drug-related problems at hospital admission.
European Journal of Clinical Pharmacology 2020;76(12):1683-1693.
https://doi.org/10.1007/s00228-020-02953-6
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Tahir Sibgha, Wagner Andreas H., Dietzel Steffen, Mannell Hanna, Pircher Joachim, Weckbach Ludwig T., Hecker Markus, Pohl Ulrich.
Endothelial CD40 mediates microvascular von Willebrand factor-dependent platelet adhesion inducing inflammatory venothrombosis in ADAMTS13 knockout mice.
Thrombosis and Haemostasis 2020;120(3):466-476.
https://doi.org/10.1055/s-0040-1702228
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Kraemer Bjoern F., Geimer Marc, Franz-Wachtel Mirita, Lamkemeyer Tobias, Mannell Hanna, Lindemann Stephan.
Extracellular matrix-specific platelet activation leads to a differential translational response and protein de novo synthesis in human platelets.
International Journal of Molecular Sciences 2020;21(21):8155.
https://doi.org/10.3390/ijms21218155
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Immler Roland, Lange-Sperandio B?rbel, Steffen Tobias, Beck Heike, Rohwedder Ina, Roth Jonas, Napoli Matteo, Hupel Georg, Pfister Frederik, Popper Bastian, Uhl Bernd, Mannell Hanna, Reichel Christoph A., Vielhauer Volker, Scherberich Jürgen, Sperandio Markus, Pruenster Monika.
Extratubular polymerized uromodulin induces leukocyte recruitment and inflammation in vivo.
Frontiers in Immunology 2020;11:588245.
https://doi.org/10.3389/fimmu.2020.588245
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Strobach Dorothea, Poppele Angelika, Mannell Hanna, Andraschko Monika, Schiek Susanne, Bertsche Thilo.
Screening for impaired liver function as a risk factor for drug safety at hospital admission of surgical patients.
International Journal of Clinical Pharmacy 2020;42(1):124-131.
https://doi.org/10.1007/s11096-019-00948-7
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Heun Yvonn, Gr?ff Pascal, Lagara Aikaterini, Schelhorn Romina, Mettler Ramona, Pohl Ulrich, Mannell Hanna.
The GEF cytohesin-2/ARNO mediates resistin induced phenotypic switching in vascular smooth muscle cells.
Scientific Reports 2020;10(1):3672.
https://doi.org/10.1038/s41598-020-60446-z
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2019
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Pogoda Kristin, Kameritsch P., Mannell Hanna, Pohl U..
Connexins in the control of vasomotor function.
Acta Physiologica 2019;225(1):e13108.
https://doi.org/10.1111/apha.13108
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Kraemer Bjoern F., Mannell Hanna, Lamkemeyer Tobias, Franz-Wachtel Mirita, Lindemann Stephan.
Heat-shock protein 27 (HSPB1) is upregulated and phosphorylated in human platelets during ST-elevation myocardial infarction.
International Journal of Molecular Sciences 2019;20(23):5968.
https://doi.org/10.3390/ijms20235968
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Heun Yvonn, Pircher Joachim, Czermak Thomas, Bluem Philipp, Hupel Georg, Bohmer Monica, Kraemer Bjoern F., Pogoda Kristin, Pfeifer Alexander, Woernle Markus, Ribeiro Andrea, Hübner Max, Kreth Simone, Claus Ralf A., Weis Sebastian, Ungelenk Luisa, Kr?tz Florian, Pohl Ulrich, Mannell Hanna.
Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in sepsis.
EBioMedicine 2019;42:120-132.
https://doi.org/10.1016/j.ebiom.2019.03.034
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Rieck Sarah, Heun Yvonn, Heidsieck Alexandra, Mykhaylyk Olga, Pfeifer Alexander, Gleich Bernhard, Mannell Hanna, Wenzel Daniela.
Local anti-angiogenic therapy by magnet-assisted downregulation of SHP2 phosphatase.
Journal of Controlled Release 2019;305:155-164.
https://doi.org/10.1016/j.jconrel.2019.05.031
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Kameritsch Petra, Kiemer Felizitas, Mannell Hanna, Beck Heike, Pohl Ulrich, Pogoda Kristin.
PKA negatively modulates the migration enhancing effect of Connexin 43.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2019;1866(5):828-838.
https://doi.org/10.1016/j.bbamcr.2019.02.001
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Grundler Groterhorst Katharina, Mannell Hanna, Pircher Joachim, Kraemer Bjoern F..
Platelet proteasome activity and metabolism is upregulated during bacterial sepsis.
International Journal of Molecular Sciences 2019;20(23):5961.
https://doi.org/10.3390/ijms20235961
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Heun Yvonn, Grundler Groterhorst Katharina, Pogoda Kristin, Kraemer Bjoern F., Pfeifer Alexander, Pohl Ulrich, Mannell Hanna.
The phosphatase SHP-2 activates HIF-1α in wounds in vivo by inhibition of 26S proteasome activity.
International Journal of Molecular Sciences 2019;20(18):4404.
https://doi.org/10.3390/ijms20184404
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Strobach Dorothea, Mannell Hanna.
Tyrosinkinaseinhibitoren beeinflussen renale Transporter: was bedeutet das für die klinische Praxis?.
Krankenhauspharmazie 2019;40(2):70-77.
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2018
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Pircher Joachim, Czermak Thomas, Ehrlich Andreas, Eberle Clemens, Gaitzsch Erik, Margraf Andreas, Grommes Jochen, Saha Prakash, Titova Anna, Ishikawa-Ankerhold Hellen, Stark Konstantin, Petzold Tobias, Stocker Thomas, Weckbach Ludwig T., Novotny Julia, Sperandio Markus, Nieswandt Bernhard, Smith Alberto, Mannell Hanna, Walzog Barbara, Horst David, Soehnlein Oliver, Massberg Steffen, Schulz Christian.
Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation.
Nature Communications 2018;9(1):1523.
https://doi.org/10.1038/s41467-018-03925-2
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Brettner Florian, Darling Joshua, Baeuml Edith-Cathrin, Mannell Hanna, Frank Hans-Georg, Amini Martina, Hulde Nikolai, Kammerer Tobias, Becker Bernhard F., Rehm Markus, Conzen Peter, Chappell Daniel.
Chances and limitations of isolated mouse heart models for investigating the endothelial glycocalyx1.
Clinical Hemorheology and Microcirculation 2018;69(3):393-403.
https://doi.org/10.3233/ch-170327
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2017
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Gaitzsch Erik, Czermak Thomas, Ribeiro Andrea, Heun Yvonn, Bohmer Monica, Merkle Monika, Mannell Hanna, Schulz Christian, W?rnle Markus, Pircher Joachim.
Double-stranded DNA induces a prothrombotic phenotype in the vascular endothelium.
Scientific Reports 2017;7(1):1112.
https://doi.org/10.1038/s41598-017-01148-x
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Heun Yvonn, Pogoda Kristin, Anton Martina, Pircher Joachim, Pfeifer Alexander, Woernle Markus, Ribeiro Andrea, Kameritsch Petra, Mykhaylyk Olga, Plank Christian, Kroetz Florian, Pohl Ulrich, Mannell Hanna.
HIF-1α dependent wound healing angiogenesis in?vivo can be controlled by site-specific lentiviral magnetic targeting of SHP-2.
Molecular Therapy 2017;25(7):1616-1627.
https://doi.org/10.1016/j.ymthe.2017.04.007
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Pogoda Kristin, Mannell Hanna, Blodow Stephanie, Schneider Holger, Schubert Kai Michael, Qiu Jiehua, Schmidt Andreas, Imhof Axel, Beck Heike, Tanase Laurentia Irina, Pfeifer Alexander, Pohl Ulrich, Kameritsch Petra.
NO augments endothelial reactivity by reducing myoendothelial calcium signal spreading: a novel role for Cx37 (Connexin 37) and the protein tyrosine phosphatase SHP-2.
Arteriosclerosis, Thrombosis, and Vascular Biology 2017;37(12):2280-2290.
https://doi.org/10.1161/atvbaha.117.309913
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Heun Yvonn, Hildebrand Staffan, Heidsieck Alexandra, Gleich Bernhard, Anton Martina, Pircher Joachim, Ribeiro Andrea, Mykhaylyk Olga, Eberbeck Dietmar, Wenzel Daniela, Pfeifer Alexander, Woernle Markus, Kr?tz Florian, Pohl Ulrich, Mannell Hanna.
Targeting of magnetic nanoparticle-coated microbubbles to the vascular wall empowers site-specific lentiviral gene delivery in vivo.
Theranostics 2017;7(2):295-307.
https://doi.org/10.7150/thno.16192
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2016
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Blüm Philipp, Pircher Joachim, Merkle Monika, Czermak Thomas, Ribeiro Andrea, Mannell Hanna, Kr?tz Florian, Hennrich Alexander, Spannagl Michael, K?ppel Simone, Gaitzsch Erik, W?rnle Markus.
Arterial thrombosis in the context of HCV-associated vascular disease can be prevented by protein C.
Cellular & Molecular Immunology 2016;14(12):986-996.
https://doi.org/10.1038/cmi.2016.10
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Chillo Omary, Kleinert Eike?Christian, Lautz Thomas, Lasch Manuel, Pagel Judith-Irina, Heun Yvonn, Troidl Kerstin, Fischer Silvia, Caballero-Martinez Amelia, Mauer Annika, Kurz Angela?R.M., Assmann Gerald, Rehberg Markus, Kanse Sandip?M., Nieswandt Bernhard, Walzog Barbara, Reichel Christoph?A., Mannell Hanna, Preissner Klaus?T., Deindl Elisabeth.
Perivascular mast cells govern shear stress-induced arteriogenesis by orchestrating leukocyte function.
Cell Reports 2016;16(8):2197-2207.
https://doi.org/10.1016/j.celrep.2016.07.040
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Grundler Katharina, Rotter Raffaela, Tilley Sloane, Pircher Joachim, Czermak Thomas, Yakac Mustaf, Gaitzsch Erik, Massberg Steffen, Kr?tz Florian, Sohn Hae-Young, Pohl Ulrich, Mannell Hanna, Kraemer Bjoern F.
The proteasome regulates collagen-induced platelet aggregation via nuclear-factor-kappa-B (NF?B) activation.
Thrombosis Research 2016;148:15-22.
https://doi.org/10.1016/j.thromres.2016.10.009
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2015
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Merkle Monika, Pircher Joachim, Mannell Hanna, Kr?tz Florian, Blüm Philipp, Czermak Thomas, Gaitzsch Erik, Schneider Christine, K?ppel Simone, Ribeiro Andrea, W?rnle Markus.
LL37 inhibits the inflammatory endothelial response induced by viral or endogenous DNA.
Journal of Autoimmunity 2015;65:19-29.
https://doi.org/10.1016/j.jaut.2015.07.015
BibTeX | RIS | DOI
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Alig Stefan K., Stampnik Yvonn, Pircher Joachim, Rotter Raffaela, Gaitzsch Erik, Ribeiro Andrea, W?rnle Markus, Kr?tz Florian, Mannell Hanna.
The tyrosine phosphatase SHP-1 regulates hypoxia inducible factor-1α (HIF-1α) protein levels in endothelial cells under hypoxia.
PLoS ONE 2015;10(3):e0121113.
https://doi.org/10.1371/journal.pone.0121113
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2014
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Pircher Joachim, Czermak Thomas, Merkle Monika, Mannell Hanna, Kr?tz Florian, Ribeiro Andrea, Vielhauer Volker, Nadjiri Jonathan, Gaitzsch Erik, Niemeyer Markus, Porubsky Stefan, Gr?ne Hermann-Josef, W?rnle Markus.
Hepatitis C virus induced endothelial inflammatory response depends on the functional expression of TNFα receptor subtype 2.
PLoS ONE 2014;9(11):e113351.
https://doi.org/10.1371/journal.pone.0113351
PDF | BibTeX | RIS | DOI
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Mannell Hanna, Krotz Florian.
SHP-2 regulates growth factor dependent vascular signalling and function.
Mini-Reviews in Medicinal Chemistry 2014;14(6):471-483.
https://doi.org/10.2174/1389557514999140506094738
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2013
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Koch Elisabeth, Pircher Joachim, Czermak Thomas, Gaitzsch Erik, Alig Stefan, Mannell Hanna, Niemeyer Markus, Kr?tz Florian, W?rnle Markus.
The endothelial tyrosine phosphatase SHP-1 plays an important role for vascular haemostasis in TNFα-induced inflammation in vivo.
Mediators of Inflammation 2013;2013:279781.
https://doi.org/10.1155/2013/279781
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2012
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Pircher Joachim, Fochler Franziska, Czermak Thomas, Mannell Hanna, Kraemer Bjoern F., W?rnle Markus, Sparatore Anna, Del Soldato Piero, Pohl Ulrich, Kr?tz Florian.
Hydrogen sulfide–releasing aspirin derivative ACS14 exerts strong antithrombotic effects in vitro and in vivo.
Arteriosclerosis, Thrombosis, and Vascular Biology 2012;32(12):2884-2891.
https://doi.org/10.1161/atvbaha.112.300627
BibTeX | RIS | DOI
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Pircher Joachim, Merkle Monika, W?rnle Markus, Ribeiro Andrea, Czermak Thomas, Stampnik Yvonn, Mannell Hanna, Niemeyer Markus, Vielhauer Volker, Kr?tz Florian.
Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and require TNF-alpha receptor subtype 2.
Arthritis Research & Therapy 2012;14(5):R225.
https://doi.org/10.1186/ar4064
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Merkle Monika, Ribeiro Andrea, Belling Franziska, Mannell Hanna, Kr?tz Florian, Pircher Joachim, W?rnle Markus.
Response of VEGF to activation of viral receptors and TNFα in human mesangial cells.
Molecular and Cellular Biochemistry 2012;370(1-2):151-161.
https://doi.org/10.1007/s11010-012-1406-8
BibTeX | RIS | DOI
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Mannell Hanna, Pircher Joachim, Fochler Franziska, Stampnik Yvonn, R?thel Thomas, Gleich Bernhard, Plank Christian, Mykhaylyk Olga, Dahmani Chiheb, W?rnle Markus, Ribeiro Andrea, Pohl Ulrich, Kr?tz Florian.
Site directed vascular gene delivery in vivo by ultrasonic destruction of magnetic nanoparticle coated microbubbles.
Nanomedicine: Nanotechnology, Biology and Medicine 2012;8(8):1309-1318.
https://doi.org/10.1016/j.nano.2012.03.007
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Merkle Monika, Ribeiro Andrea, K?ppel Simone, Pircher Joachim, Mannell Hanna, Roeder Maximilian, W?rnle Markus.
TLR3-dependent immune regulatory functions of human mesangial cells.
Cellular & Molecular Immunology 2012;9(4):334-340.
https://doi.org/10.1038/cmi.2012.3
BibTeX | RIS | DOI
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Mannell Hanna, Pircher Joachim, R?thel Thomas, Schilberg Katharina, Zimmermann Katrin, Pfeifer Alexander, Mykhaylyk Olga, Gleich Bernhard, Pohl Ulrich, Kr?tz Florian.
Targeted endothelial gene delivery by ultrasonic destruction of magnetic microbubbles carrying lentiviral vectors.
Pharmaceutical Research 2012;29(5):1282-1294.
https://doi.org/10.1007/s11095-012-0678-8
BibTeX | RIS | DOI
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2011
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Mannell Hanna, Pircher Joachim, Chaudhry Daniel I., Alig Stefan K.C., Koch Elisabeth G., Mettler Ramona, Pohl Ulrich, Kr?tz Florian.
ARNO regulates VEGF-dependent tissue responses by stabilizing endothelial VEGFR-2 surface expression.
Cardiovascular Research 2011;93(1):111-119.
https://doi.org/10.1093/cvr/cvr265
BibTeX | RIS | DOI
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R?thel T., Mannell Hanna, Pircher Joachim, Gleich B., Pohl Ulrich, Kr?tz F..
Magnetic stents retain nanoparticle-bound antirestenotic drugs transported by lipid microbubbles.
Pharmaceutical Research 2011;29(5):1295-1307.
https://doi.org/10.1007/s11095-011-0643-y
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2010
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Mannell Hanna, Hammitzsch Ariane, Mettler Ramona, Pohl Ulrich, Kr?tz Florian.
Suppression of DNA-PKcs enhances FGF-2 dependent human endothelial cell proliferation via negative regulation of Akt.
Cellular Signalling 2010;22(1):88-96.
https://doi.org/10.1016/j.cellsig.2009.09.015
BibTeX | RIS | DOI
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2009
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Krotz F., Hellwig N., Burkle M. A., Lehrer S., Riexinger T., Mannell Hanna, Sohn H.-Y., Klauss V., Pohl U..
A sulfaphenazole-sensitive EDHF opposes platelet-endothelium interactions in vitro and in the hamster microcirculation in vivo.
Cardiovascular Research 2009;85(3):542-550.
https://doi.org/10.1093/cvr/cvp301
BibTeX | RIS | DOI
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Struthmann L., Hellwig N., Pircher J., Sohn H.‐Y., Buerkle M.A., Klauss V., Mannell Hanna, Pohl U., Kr?tz F..
Prothrombotic effects of diclofenac on arteriolar platelet activation and thrombosis in?vivo.
Journal of Thrombosis and Haemostasis 2009;7(10):1727-1735.
https://doi.org/10.1111/j.1538-7836.2009.03582.x
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2007
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Gleich Bernhard, Hellwig Nicole, Bridell Hanna, Jurgons Roland, Seliger Christian, Alexiou Christoph, Wolf Bernhard, Weyh Thomas.
Design and evaluation of magnetic fields for nanoparticle drug targeting in cancer.
IEEE Transactions On Nanotechnology 2007;6(2):164-170.
https://doi.org/10.1109/tnano.2007.891829
BibTeX | RIS | DOI
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Mannell Hanna, Hellwig Nicole, Gloe Torsten, Plank Christian, Sohn Hae-Young, Groesser Leopold, Walzog Barbara, Pohl Ulrich, Kr?tz Florian.
Inhibition of the tyrosine phosphatase SHP-2 suppresses angiogenesis in vitro and in vivo.
Journal of Vascular Research 2007;45(2):153-163.
https://doi.org/10.1159/000110081
BibTeX | RIS | DOI
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Kro?tz Florian, Sohn Hae-Young, Mannell Hanna.
Letter by Kro?tz et al regarding article, “Improvement of peripheral endothelial dysfunction by protein tyrosine phosphatase inhibitors in heart failure”.
Circulation 2007;115(25):e648.
https://doi.org/10.1161/circulationaha.107.690354
BibTeX | RIS | DOI
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Mannell Hanna, Krotz Florian.
The role of SHP-2 in cell signalling and human disease.
Current Enzyme Inhibition 2007;3(4):264-272.
https://doi.org/10.2174/157340807782330264
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2005
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Kr?tz Florian, Engelbrecht Barbara, Buerkle Martin A., Bassermann Florian, Bridell Hanna, Gloe Torsten, Duyster Justus, Pohl Ulrich, Sohn Hae-Young.
The tyrosine phosphatase, SHP-1, is a negative regulator of endothelial superoxide formation.
Journal of the American College of Cardiology 2005;45(10):1700-1706.
https://doi.org/10.1016/j.jacc.2005.02.039
BibTeX | RIS | DOI
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