拉斯维加斯赌城

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Airborne stressors such as ambient air pollution, including particulate matter and allergens not only directly compromise pulmonary health by promoting chronic airway inflammation, bronchial obstruction or airway hyperresponsiveness but also facilitate the development of chronic systemic inflammation that may compromise tissue integrity of other vital organs. While respiratory tract responses to airborne stressors may appear as recognizable consequences, such as sneezing, coughing or wheezing, effects on other tissues may go unnoticed. Particularly, compromised cerebro- and cardiovascular health in response to acute and chronic exposures to airborne stressors highlights the health risks of ambient air pollution also with respect to stroke. However, mechanistic insights into how exposures to airborne stressors contribute to increased occurrence of cerebrovascular events or worsen their outcome are not yet available.?

?Zerebrales Blutgef?? mit Astrozyten (rot), Endothelzellen (blau) und Basallamina mit grüner Autofluoreszenz.

Related Publications

Malm Tillgren Sofia, Nieto-Fontarigo Juan José, Cerps Samuel, Ramu Sangeetha, Menzel Mandy, Mahmutovic Persson Irma, Meissner Anja, Akbarshahi Hamid, Uller Lena. C57Bl/6N mice have an attenuated lung inflammatory response to dsRNA compared to C57Bl/6J and BALB/c mice. https://doi.org/10.1186/s12950-023-00331-4
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Sex-specific cardiovascular consequences of high dietary salt intake


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According to the World Health Organization, most people consume too much salt - on average 9–12 grams per day, which is around twice the recommended maximum level of intake. Excess dietary sodium has been linked to elevations in blood pressure, and recent pre-clinical and clinical data support that even in the absence of an increase in blood pressure, excess dietary salt can adversely affect target organs, including the blood vessels, heart, kidneys, and brain.?

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Notably, epidemiological studies have suggested sex-specific differences, with a higher prevalence of salt sensitivity observed in women compared to men. However, knowledge of salt-sensitive mechanisms is largely restricted to males, while female-specific studies on the topic are scarce.?

?Metabolische Profile von Kortex und Hippocampus als Reaktion auf salzreiche Ern?hrung und Alterung. Dargestellt sind repr?sentative MRS-Spektren für den Kortex (a) und den Hippocampus (b). Das resultierende neurochemische Profil wurde mittels PLS-Regression auf das Vorhandensein hoher Salzkonzentrationen in der Nahrung analysiert. (c) Komponenten nach PLS-Regression mit einzelnen M?usen (Symbole) und Gruppen-SDs (Ellipsoide) für normale (ND), salzreiche (HSD) und inverse (Rev) Di?tgruppen nach 0, 7 und 14 Monaten Behandlung. (d,e) VIP-Scores, berechnet aus dem resultierenden PLS-Modell für Metaboliten im Kortex und Hippocampus.

Related Funding

Albert P?hlsson Stiftelse: Sex-specific cardiovascular consequences of high in dietary salt consumption - funding period 2022 – 2025
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Crafoordska Stiftelse: Preclinical MR imaging of neurological and cardiovascular diseases (together with Lund University Bioimaging Centre) - funding period 2025 – 2026

Related Publications

Meissner Anja, Garcia-Serrano Alba M., Vanherle Lotte, Rafiee Zeinab, Don-Doncow Nicholas, Skoug Cecilia, Larsson Sara, Gottschalk Michael, Magnusson Martin, Duarte Jo?o M. N.. Alterations to cerebral perfusion, metabolite profiles, and neuronal morphology in the hippocampus and cortex of male and female mice during chronic exposure to a high-salt diet. https://doi.org/10.3390/ijms24010300
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Don-Doncow Nicholas, Vanherle Lotte, Zhang Yun, Meissner Anja. T-Cell accumulation in the hypertensive brain: a role for sphingosine-1-phosphate-mediated chemotaxis. https://doi.org/10.3390/ijms20030537
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Meissner Anja, Minnerup Jens, Soria Guadalupe, Planas Anna M. Structural and functional brain alterations in a murine model of Angiotensin II-induced hypertension. https://doi.org/10.1111/jnc.13905
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Effect of high diet on brain function


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Cardiovascular risk factor often arise as a result of a combination of unhealthy diet and sedentary lifestyle and have negative effects on the brain vasculature, brain metabolism and brain function in general. Moreover, they not only increase the risk of acute cerebrovascular event, such as stroke, but also affect ?their outcomes. ?

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?MRT Aufnahme einer kortikalen L?sion nach Schlaganfall.
?Dendritische Dornenforts?tze eines pyramidalen Neurons im Kortex.
?Intermedi?rfilament Expression in kortikalen Astrozyten auf Einzeltranskriptniveau.

Related Publications

Skoug Cecilia, Erdogan Hüseyin, Vanherle Lotte, Vieira Jo?o P. P., Matthes Frank, Eliasson Lena, Meissner Anja, Duarte Jo?o M. N.. Density of sphingosine-1-phosphate receptors is altered in cortical nerve-terminals of insulin-resistant Goto-Kakizaki rats and diet-induced obese mice. https://doi.org/10.1007/s11064-023-04033-4
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Jujic Amra, Vieira Jo?o P. P., Matuskova Hana, Nilsson Peter M., Lindblad Ulf, Olsen Michael H., Duarte Jo?o M. N., Meissner Anja, Magnusson Martin. Plasma galectin-4 levels are increased after stroke in mice and humans. https://doi.org/10.3390/ijms241210064
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Effects of the Incretin system on the cardiovascular system?


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Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) regulate islet function, nutrient absorption, appetite, and energy homeostasis, making them potential diabetes treatments. G-protein coupled receptors for these peptides are also expressed in the cardiovascular system, sparking interest in their relevance to cardiovascular disease (CVD). Most research has focused on GLP-1, with clinical trials showing its benefits beyond blood glucose control. However, with increasing use of dipeptidyl peptidase-4 (DPP-4) inhibitors, which elevate both GLP-1 and GIP levels, understanding GIP's cardiovascular effects is crucial. DPP-4 inhibitors have been linked to increased heart failure risk in some patients. The newest dual GIP and GLP-1 receptor agonists heighten the need to understand GIP's potential adverse effects on CVD.

?Blutgef?? mit umgebenden Gewebemakrophagen (rot).

Related Funding

Vetenskapsr?det:?Inkretinsystemets inverkan p? hj?rt-k?rlsjukdom och cancer?-?funding period 2023 - 2026

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