CTLA4 promoter hypomethylation is a negative prognostic biomarker at initial diagnosis but predicts response and favorable outcome to anti-PD-1 based immunotherapy in clear cell renal cell carcinoma
Niklas Klümper, Damian J Ralser, Romina Zarbl, Katrin Schlack, Andres Jan Schrader, Marc Rehlinghaus, Michèle J Hoffmann, Günter Niegisch, Annemarie Uhlig, Lutz Trojan, Julie Steinestel, Konrad Steinestel, Ralph M Wirtz, Danijel Sikic, Markus Eckstein, Glen Kristiansen, Marieta Toma, Michael H?lzel, Manuel Ritter, Sebastian Strieth, J?rg Ellinger, Dimo Dietrich
J Immunother Cancer. 2021; 9(8): e002949. Published online 2021 Aug 26. doi: 10.1136/jitc-2021-002949. PMCID: PMC8395367
A prognostic score for overall survival in patients treated with abiraterone in the pre- and post-chemotherapy setting. Oncotarget.
Boegemann M, Schlack K, Früchtenicht L, Steinestel J, Schrader AJ, Wennmann
Y, Krabbe LM, Eminaga O.
2019 Aug 20;10(49):5082-5091. doi: 10.18632/oncotarget.27133. PMID: 31489117;
PMCID: PMC6707939.
Comparative Analysis of AR Variant AR-V567es mRNA Detection Systems Reveals Eminent Variability and Questions the Role as a Clinical Biomarker in Prostate Cancer. Bernemann C, Humberg V, Thielen B, Steinestel J, Chen X, Duensing S, Schrader AJ, Boegemann M.
Clin Cancer Res. 2019 Jul 1;25(13):3856-3864. doi: 10.1158/1078-0432.CCR-18-4276. Epub 2019 Apr 16. PMID: 30992298.
Expression levels of hnRNP K and p21WAF1/CIP1 are associated with resistance to radiochemotherapy independent of p53 pathway activation in rectal adenocarcinoma. Daskalaki W, Wardelmann E, Port M, Stock K, Steinestel J, Huss S, Sperveslage J, Steinestel K, Eder S. Int J Mol Med. 2018 Dec;42(6):3269-3277. doi:10.3892/ijmm.2018.3898. Epub 2018 Sep 25. PMID: 30272263; PMCID:PMC6202084.
Performance comparison of two androgen receptor splice variant 7 (AR-V7)
detection methods. Bernemann C, Steinestel J, Humberg V, B?gemann M, Schrader AJ, Lennerz JK BJU Int. 2018 Aug;122(2):219-226. doi: 10.1111/bju.14146. Epub 2018 Feb 14. PMID: 29359890.
Comparison of isolation platforms for detection of circulating renal cell carcinoma cells. Maertens Y, Humberg V, Erlmeier F, Steffens S, Steinestel J, B?gemann M, Schrader AJ, Bernemann C
Oncotarget. 2017 Sep 23;8(50):87710-87717. doi: 10.18632/oncotarget.21197. PMID: 29152114; PMCID: PMC5675666.
Re: Emmanuel S. Antonarakis, Changxue Lu, Brandon Luber, et al. Clinical Significance of Androgen Receptor Splice Variant-7 mRNA Detection in Circulating Tumor Cells of Men with Metastatic Castration-resistant Prostate Cancer Treated with First- and Second-line Abiraterone and Enzalutamide.
Steinestel J, Bernemann C, Schrader AJ, Lennerz JK.
J Clin Oncol 2017;35:2149-56: AR-V7 Testing: What's in it for the Patient? Eur Urol. 2017 Dec;72(6):e168-e169. doi:10.1016/j.eururo.2017.06.031. Epub 2017 Jul 5. PMID: 28688614.
Influence of serum cholesterol level and statin treatment on prostate cancer aggressiveness. Schnoeller TJ, Jentzmik F, Schrader AJ, Steinestel J
Oncotarget. 2017 Jul 18;8(29):47110-47120. doi: 10.18632/oncotarget.16943. PMID:28445145; PMCID: PMC5564548.
Resistenzentwicklung und pr?diktive Marker beim metastasierten Prostatakarzinom. Bernemann C, B?gemann M, Steinestel J, Schrader AJ
Oncol Res Treat. 2017;40 Suppl 2:8-10. German. doi: 10.1159/000456167. Epub 2017 Apr 3. PMID: 28365708.
Novel AR-V7 detectionin whole blood samples in patients with prostate cancer: not as simple as it seems. Bernemann C, Steinestel J, Boegemann M, Schrader AJ. World J Urol. 2017 Oct;35(10):1625-1627. doi: 10.1007/s00345-017-2024-6. Epub 2017 Feb 28. PMID: 28243791.
The Role of the Neutrophil to Lymphocyte Ratio for Survival Outcomes in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with Abiraterone. Boegemann M, Schlack K, Thomes S, Steinestel J, Rahbar K, Semjonow A, Schrader AJ, Aringer M, Krabbe LM. Int J Mol Sci. 2017 Feb 11;18(2):380. doi: 10.3390/ijms18020380. PMID: 28208664; PMCID: PMC5343915.
Variant histology in bladder cancer: how it should change the management in non-muscle invasive and muscle invasive disease?
Klaile Y, Schlack K, Boegemann M, Steinestel J, Schrader AJ, Krabbe LM
Transl Androl Urol. 2016, Oct;5(5):692-701. doi: 10.21037/tau.2016.06.13. PMID: 27785426; PMCID:PMC5071184.
Reply to Marcus V. Cronauer, Axel S. Merseburger, and M. Raschid Hoda's Letter to the Editor re: Christof Bernemann, Thomas J. Schnoeller, Manuel Luedeke, et al. Expression of AR-V7 in Circulating Tumour Cells Does Not Preclude Response to Next Generation Androgen Deprivation Therapy in Patients with Castration Resistant Prostate Cancer. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2016.07.021.
Reply from Authors re: Emmanuel S. Antonarakis, Howard I. Scher. Do Patients With AR-V7- Positive Prostate Cancer Benefit from Novel Hormonal Therapies? It All Depends on Definitions. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2016.08.038: Unsplicing a Conflict. Steinestel J, Bernemann C, Schrader AJ, Lennerz JK.
Eur Urol. 2016 Sep 15. pii: S0302-2838(16)30583-8. doi:10.1016/j.eururo.2016.08.071. [Epub ahead of print] PMID: 27641787
Expression of AR-V7 in Circulating Tumour Cells Does Not Preclude Response to Next Generation Androgen Deprivation Therapy in Patients with Castration Resistant Prostate Cancer. Bernemann C, Schnoeller TJ, Luedeke M, Steinestel K, Boegemann M, Schrader AJ, Steinestel J.
Eur Urol. 2016 Jul 25. pii: S0302-2838(16)30426-2. doi:10.1016/j.eururo.2016.07.021. [Epubahead of print], PMID: 27471164
The safety and efficacy of gemcitabine for the treatment of bladder cancer. Schlack K, Boegemann M, Steinestel J, Schrader AJ, Krabbe LM. Expert Rev Anticancer Ther. 2016;16(3):255-71. doi:10.1586/14737140.2016.1143777. Epub 2016 Feb 9.PMID: 26781169
Influence of Statins on Survival Outcome in Patients with Metastatic Castration Resistant Prostate Cancer Treated with Abiraterone Acetate. Boegemann M, Schlack K, Fischer AK, Ger? J, Steinestel J, Semjonow A, Schrader AJ, Krabbe LM. PLoS One. 2016 Sep 1;11(9):e0161959. doi: 10.1371/journal.pone.0161959. eCollection 2016.
The small conductance potassium-activated calcium channel 3 (SK3) is a molecular target for Edelfosine to reduce the invasive potential of urothelial carcinoma cells. Steinestel K*, Eder S*, Ehinger K, Schneider J, Genze F, Winkler E, Wardelmann E, Schrader AJ, Steinestel J. Tumour Biology 2015 Nov 30. PMID: 26619845
Detecting predictive androgen receptor modifications in circulating prostate cancer cells. Steinestel J, Luedeke M, Arndt A, Schnoeller TJ, Lennerz JK, Wurm C, Maier C, Cronauer MV, Steinestel K, Schrader AJ.
Oncotarget. 2015 Apr 23. [Epub ahead of print] PMID: 25970787
The role of histologic subtype, p16INK4a expression, and presence of human papillomavirus DNA in penile squamous cell carcinoma. Steinestel J, Al Ghazal A, Arndt A, Schn?ller TJ, Schrader M, Schrader AJ, M?ller P,
Steinestel K. BMC Cancer. Apr. 2015; 15(1):220. PMID: 25885064
Resistance to androgen-pathway drugs in prostate cancer. Steinestel J, Schrader AJ, Luedeke M. N Engl J Med. 2014 Dec 4;371(23):2234. doi: 10.1056/NEJMc1412594#SA3.
The Fuhrman grading system has no prognostic value in patients with nonsarcomatoid chromophobe renal cell carcinoma.
Steffens S, Janssen M, Roos FC, Becker F, Steinestel J, Abbas M, Steinestel K, Wegener G, Siemer S, Thüroff JW, Hofmann R, St?ckle M, Schrader M, Hartmann A, Hasenfus A, Kuczyk MA, Junker K, Schrader AJ; German Renal Cell Cancer Network. Hum Pathol. 2014 Dec;45(12):2411-6. doi: 10.1016/j.humpath.2014.08.002. Epub 2014 Aug 23
Clinical behavior of chromophobe renal cell carcinoma is less aggressive than that of clear cell renal cell carcinoma, independent of Fuhrman grade or tumor size. Steffens S, Roos FC, Janssen M, Becker F, Steinestel J, Abbas M, Steinestel K, Wegener G, Siemer S, Thüroff JW, Hofmann R, St?ckle M, Schrader M, Hartmann A, Junker K, Kuczyk MA, Schrader AJ; German Renal Cell Cancer Network. Virchows Arch. 2014 Oct;465(4):439-44. doi: 10.1007/s00428-014-1648-9. Epub 2014 Sep 2. PMID: 25178561
Influence of ureter stenting before ureterorenoscopic treatment of ureteral calculi. Mueller J, Riechert-Mühe N, Schrader AJ, Leitenberger A, Steinestel J, Kuczyk MA, Steffens S, Hofmann R, Sotelino J.
Urologe A. 2014 Nov;53(11):1656-60. doi: 10.1007/s00120-014-3587-0.
German.PMID: 25123561
Positive surgical margins in nephron-sparing surgery: risk factors and therapeutic consequences. Steinestel J, Steffens S, Steinestel K, Schrader AJ. World J Surg Oncol. 2014 Aug 8;12:252. doi: 10.1186/1477-7819-12-252.
Overexpression of p16(INK4a) in urothelial carcinoma in situ is a marker for MAPK-mediated epithelial-mesenchymal transition but is not related to human papillomavirus infection. Steinestel J, Cronauer MV, Müller J, Al Ghazal A, Skowronek P, Arndt A, Kraft K, Schrader M, Schrader AJ, Steinestel K.
PLoS One. 2013 May 28;8(5):e65189. doi: 10.1371/journal.pone.0065189. Print 2013.
Clinical significance of epithelial-mesenchymal transition. Steinestel K, Eder S, Schrader AJ, Steinestel J. Clin Transl Med. 2014 Jul 2;3:17. doi: 10.1186/2001-1326-3-17. eCollection 2014. Review.
Capsulotomy for treatment of compartment syndrome in patients with post extracorporeal shock wave lithotripsy renal hematomas: safe and effective, but also advisable? Al Ghazal A, Schnoeller TJ, Baechle C, Steinestel J, Jentzmik F, Steffens S, Hirning C,Schrader M, Schrader AJ.
Urol J. 2014 Jul 8;11(3):1569-74.
Elevated C-reactive protein values predict nodal metastasis in patients with penile cancer. Al Ghazal A, Steffens S, Steinestel J, Lehmann R, Schnoeller TJ, Schulte-Hostede A, Wegener G, Jentzmik F, Schrader M, Kuczyk MA, Schrader AJ. BMC Urol. 2013 Oct 22;13:53. doi: 10.1186/1471-2490-13-53.
High CRP values predict poor survival in patients with penile cancer. Steffens S, Al Ghazal A, Steinestel J, Lehmann R, Wegener G, Schnoeller TJ, Cronauer MV, Jentzmik F, Schrader M, Kuczyk MA, Schrader AJ. BMC Cancer. 2013 May 3;13:223. doi: 10.1186/1471-2407-13-223.
Expression of Abelson interactor 1 (Abi1) correlates with inflammation, KRAS mutation and adenomatous change during colonic carcinogenesis. Steinestel K, Brüderlein S, Steinestel J, M?rkl B, Schwerer MJ, Arndt A, Kraft K, Pr?pper C, M?ller P. PLoS One. 2012;7(7):e40671. doi: 10.1371/journal.pone.0040671. Epub 2012 Jul 10.
The use of Surgisis? optimizes and simplifies partial nephrectomy for large renal tumors. T J Schnoeller, R de Petriconi, R Hefty, F Jentzmik, A Al Ghazal, J Steinestel, J Mueller, F Zengerling, M Schrader, A J Schrader Klink für Urologie, Universit?tsklinikum Ulm, Prittwitzstra?e 43, 89075, Ulm, Deutschland. Der Urologe. 11/2012; DOI:10.1007/s00120-012-3050-z Source: PubMed
Expression of Abelson interactor 1 (Abi1) correlates with inflammation, KRAS mutation and adenomatous change during colonic carcinogenesis. Steinestel K, Brüderlein S, Steinestel J, M?rkl B, Schwerer MJ, Arndt A, Kraft K, Pr?pper C, M?ller P. PLoS One. 2012;7(7):e40671. doi: 10.1371/journal.pone.0040671. Epub 2012 Jul 10
Heterogeneous nuclear ribonucleoprotein k interacts with Abi-1 at postsynaptic sites and modulates dendritic spine morphology. Proepper C, Steinestel K, Schmeisser MJ, Heinrich J, Steinestel J, Bockmann J, Liebau S, Boeckers TM. PLoS One. 2011;6(11):e27045. doi: 10.1371/journal.pone.0027045. Epub 2011 Nov 15.
An SK3 channel/nWASP/Abi-1 complex is involved in early neurogenesis. Liebau S, Steinestel J, Linta L, Kleger A, Storch A, Schoen M, Steinestel K, Proepper C, Bockmann J, Schmeisser MJ, Boeckers TM.
PLoS One. 2011 Mar 25;6(3):e18148. doi: 10.1371/journal.pone.0018148.
